Journal of the American College of Cardiology
Clinical research: meta-analysis
The optimal intensity of vitamin k antagonists in patients with mechanical heart valvesA meta-analysis
Roel Vink, Roderik A. Kraaijenhagen, Barbara A. Hutten, Renee B.A. van den Brink, Bas A. de Mol, Harry R. Büller and Marcel Levi
Table 4
Table 4
Incidence Rates of Thromboembolic and Hemorrhagic Complications in Patients With Mechanical Mitral Valve, According to Vitamin K Antagonist Intensity
| Events/1,000 Pt-Yrs | Risk Ratio | 95% CI | p Value | ||
|---|---|---|---|---|---|
| Mitral Valve High | Mitral Valve Low | ||||
| VT | 2.06 | 3.44 | 0.60 | 0.47–0.76 | <0.0001 |
| TE | 15.91 | 20.12 | 0.79 | 0.74–0.84 | <0.0001 |
| VT+TE | 17.11 | 23.13 | 0.74 | 0.70–0.78 | <0.0001 |
| Hemor | 12.94 | 11.96 | 1.08 | 1.00–1.16 | 0.0524 |
| All | 29.76 | 35.33 | 0.84 | 0.79–0.89 | <0.0001 |
Abbreviations as in Tables 1 and 3.
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