Author + information
- Received February 17, 2003
- Revision received August 7, 2003
- Accepted August 15, 2003
- Published online May 19, 2004.
- Whady Hueb, MD*,* ( )(, )
- Paulo R Soares, MD*,
- Bernard J Gersh, MB, ChB, DPhil†,
- Luiz A.M César, MD*,
- Protásio L Luz, MD, FACC*,
- Luiz B Puig, MD*,
- Eulógio M Martinez, MD, FACC*,
- Sergio A Oliveira, MD* and
- José A.F Ramires, MD, FACC*
- ↵*Reprint requests and correspondence:
Dr. Whady Hueb, Instituto do Coração, HC-FMUSP, Divisão Clinica, Av. Dr. Enéias de Carvalho Aguiar 44, Cerqueira César, São Paulo/SP, Brazil.
Objectives We sought to evaluate the relative efficacies of three possible therapeutic strategies for patients with multivessel coronary artery disease (CAD), stable angina, and preserved ventricular function.
Background Despite routine use of coronary artery bypass graft surgery (CABG) and percutaneous coronary intervention (PCI), there is no conclusive evidence that either one is superior to medical therapy (MT) alone for the treatment of multivessel CAD.
Methods The primary end point was defined as cardiac mortality, Q-wave myocardial infarction (MI), or refractory angina requiring revascularization. All data were analyzed according to the intention-to-treat principle.
Results A total of 611 patients were randomly assigned to either a CABG (n = 203), PCI (n = 205), or MT (n = 203) group. The one-year survival rates were 96.0% for CABG, 95.6% for PCI, and 98.5% for MT. The rates for one-year survival free of Q-wave MI were 98% for CABG, 92% for PCI, and 97% for MT. After one-year follow-up, 8.3% of MT patients and 13.3% of PCI patients underwent to additional interventions, compared with only 0.5% of CABG patients. At one-year follow-up, 88% of the patients in the CABG group, 79% in the PCI group, and 46% in the MT group were free of angina (p < 0.0001).
Conclusions Medical therapy for multivessel CAD was associated with a lower incidence of short-term events and a reduced need for additional revascularization, compared with PCI. In addition, CABG was superior to MT for eliminating anginal symptoms. All three therapeutic regimens yielded relatively low rates of cardiac-related deaths.
☆ Financial support was provided, in part, by a research grant from the Zerbini Foundation, São Paulo, Brazil. Dr. William Weintraub acted as Guest Editor of this paper.
- Received February 17, 2003.
- Revision received August 7, 2003.
- Accepted August 15, 2003.
- American College of Cardiology Foundation