Author + information
- Received October 23, 2003
- Revision received December 5, 2003
- Accepted January 12, 2004
- Published online June 2, 2004.
- Harald P Kühl, MD*,* (, )
- Marcus Schreckenberg, PhD§,
- Dierk Rulands, MD*,
- Markus Katoh, MD†,
- Wolfgang Schäfer, MD, PhD‡,
- Georg Schummers, PhD§,
- Arno Bücker, MD†,
- Peter Hanrath, MD* and
- Andreas Franke, MD*
- ↵*Reprint requests and correspondence:
Dr. Harald P. Kühl, Medizinische Klinik I, Universitätsklinikum, Pauwelstrasse 30, 52057 Aachen, Germany.
Objectives We sought to validate high-resolution transthoracic real-time (RT) three-dimensional echocardiography (3DE), in combination with a novel semi-automatic contour detection algorithm, for the assessment of left ventricular (LV) volumes and function in patients.
Background Quantitative RT-3DE has been limited by impaired image quality and time-consuming manual data analysis.
Methods Twenty-four subjects with abnormal (n = 14) or normal (n = 10) LVs were investigated. The results for end-diastolic volume (EDV), end-systolic volume (ESV), and ejection fraction (EF) obtained by manual tracing were compared with the results determined by the semi-automatic border detection algorithm. Moreover, the results of the semi-automatic method were compared with volumes and EF obtained by cardiac magnetic resonance imaging (CMRI).
Results Excellent correlation coefficients (r = 0.98 to 0.99) and low variability (EDV −1.3 ± 8.6 ml; ESV −0.2 ± 5.4 ml; EF −0.1 ± 2.7%; p = NS) were observed between the semi-automatically and manually assessed data. The RT-3DE data correlated highly with CMRI (r = 0.98). However, LV volumes were underestimated by RT-3DE compared with CMRI (EDV −13.6 ± 18.9 ml, p = 0.002; ESV −12.8 ± 20.5 ml, p = 0.005). The difference for EF was not significant between the two methods (EF 0.9 ± 4.4%, p = NS). Observer variability was acceptable, and repeatability of the method was excellent.
Conclusions The RT-3DE, in combination with a semi-automatic contour tracing algorithm, allows accurate determination of cardiac volumes and function compared with both manual tracing and CMRI. High repeatability suggests applicability of the method for the serial follow-up of patients with cardiac disease.
☆ Drs. Schreckenberg and Schummers are employees of TomTec Imaging Systems GmbH.
- Received October 23, 2003.
- Revision received December 5, 2003.
- Accepted January 12, 2004.
- American College of Cardiology Foundation