Author + information
- Received December 10, 2003
- Revision received February 26, 2004
- Accepted March 23, 2004
- Published online July 7, 2004.
- Shiow Jiuan Lin, MS*,
- Peggy A. Brown, RDCS*,
- Mary P. Watkins, RT*,
- Todd A. Williams, RT*,
- Katherine A. Lehr, BSN*,
- Wei Liu, MS†,
- Gregory M. Lanza, MD, PhD*,
- Samuel A. Wickline, MD*,† and
- Shelton D. Caruthers, PhD*,†,‡,* ()
- ↵*Reprint requests and correspondence:
Dr. Shelton D. Caruthers, Cardiovascular Division, Washington University School of Medicine, Campus Box 8086, 660 South Euclid Avenue, St. Louis, Missouri 63110, USA.
Objectives The purpose of this study was to evaluate the reliability of the pressure half-time (PHT) method for estimating mitral valve areas (MVAs) by velocity-encoded cardiovascular magnetic resonance (VE-CMR) and to compare the method with paired Doppler ultrasound.
Background The pressure half-time Doppler echocardiography method is a practical technique for clinical evaluation of mitral stenosis. As CMR continues evolving as a routine clinical tool, its use for estimating MVA requires thorough evaluation.
Methods Seventeen patients with mitral stenosis underwent echocardiography and CMR. Using VE-CMR, MVA was estimated by PHT method. Additionally, peak E and peak A velocities were defined. Interobserver repeatability of VE-CMR was evaluated.
Results By Doppler, MVAs ranged from 0.87 to 4.49 cm2; by CMR, 0.91 to 2.70 cm2, correlating well between modalities (r = 0.86). The correlation coefficient for peak E and peak A between modalities was 0.81 and 0.89, respectively. Velocity-encoded CMR data analysis provided robust, repeatable estimates of peak E, peak A, and MVA (r = 0.99, 0.99, and 0.96, respectively).
Conclusions Velocity-encoded cardiovascular magnetic resonance can be used routinely as a robust tool to quantify MVA via mitral flow velocity analysis with PHT method.
☆ This work was supported in part by NIH grants (HL-42950, HL-63448), a research grant from Philips Medical Systems, the Edith and Alan Wolff Charitable Fund, and the Barnes-Jewish Hospital Research Foundation. Dr. Caruthers is an employee of Philips Medical Systems; Dr. Wickline receives research funding from Philips Medical Systems.
- Received December 10, 2003.
- Revision received February 26, 2004.
- Accepted March 23, 2004.
- American College of Cardiology Foundation