Author + information
- Received May 3, 2004
- Revision received September 7, 2004
- Accepted September 14, 2004
- Published online January 4, 2005.
- Allison M. Pritchett, MD*,
- Douglas W. Mahoney, MS†,
- Steven J. Jacobsen, MD, PhD‡,
- Richard J. Rodeheffer, MD, FACC*,
- Barry L. Karon, MD, FACC* and
- Margaret M. Redfield, MD, FACC*,* ()
- ↵*Reprint requests and correspondence:
Dr. Margaret M. Redfield, Guggenheim 9, Mayo Clinic, 200 First Street SW, Rochester, Minnesota 55905
Objectives We examined the association between diastolic function and left atrial volume indexed to body surface area (LAVi) in a population-based study.
Background Atrial enlargement has been suggested as a marker of the severity and duration of diastolic dysfunction (DD). However, the association between DD and atrial enlargement and their individual prognostic implications in the population is poorly defined.
Methods A cross-sectional sample of Olmsted County, Minnesota, residents ≥45 years of age (n = 2,042) underwent comprehensive Doppler echocardiography and medical record review.
Results The LAVi increased with worsening DD: 23 ± 6 ml/m2(normal), 25 ± 8 ml/m2(grade I DD), 31 ± 8 ml/m2(grade II DD), 48 ± 12 ml/m2(grades III to IV DD). In bivariate analyses, age, left ventricular mass index, and DD grade were positively associated, whereas female gender and ejection fraction (EF) were inversely associated with LAVi (p < 0.001 for all). When controlling for age, gender, cardiovascular (CV) disease, EF, and left ventricular mass, grade II DD was associated with a 24%, and grade III to IV DD was associated with a 62% larger LA volume (p < 0.0001 for both). The area under the receiver-operator characteristic curve for LAVi to detect grade I, grade II, or grade III to IV DD was 0.57, 0.81, and 0.98, respectively. Both DD and LAVi were predictive of all-cause mortality, but when controlling for DD, LAVi was not an independent predictor of mortality.
Conclusions These data suggest that DD contributes to LA remodeling. Indeed, DD is a stronger predictor of mortality; presumably it better reflects the impact of CV disease within the general population.
This study was funded by grants from the Public Health Service (NIH HL 55502 [to Dr. Rodeheffer] and NIH AR 30582 [to Dr. Jacobsen]), the Marriott Foundation, the Miami Heart Research Institute, and the Mayo Foundation. Dr. Pritchett is currently located at the Baylor College of Medicine, Houston, Texas.
- Received May 3, 2004.
- Revision received September 7, 2004.
- Accepted September 14, 2004.
- American College of Cardiology Foundation