Author + information
- Received October 25, 2004
- Revision received March 22, 2005
- Accepted March 29, 2005
- Published online July 19, 2005.
- Myeong-Ki Hong, MD⁎,
- Gary S. Mintz, MD, FACC‡,
- Cheol Whan Lee, MD⁎,
- Bong-Ki Lee, MD⁎,
- Tae-Hyun Yang, MD⁎,
- Young-Hak Kim, MD⁎,
- Jong-Min Song, MD⁎,
- Ki-Hoon Han, MD⁎,
- Duk-Hyun Kang, MD⁎,
- Sang-Sig Cheong, MD†,
- Jae-Kwan Song, MD, FACC⁎,
- Jae-Joong Kim, MD⁎,
- Seong-Wook Park, MD, FACC⁎ and
- Seung-Jung Park, MD, FACC⁎,⁎ ()
- ↵⁎Reprint requests and correspondence:
Dr. Seung-Jung Park, Department of Medicine, University of Ulsan College of Medicine, Asan Medical Center, 388-1 Poongnap-dong, Songpa-gu, Seoul, 138-736, Korea.
Objectives We evaluated the axial location of plaque ruptures in native coronary arteries.
Background It is clinically important to understand the potential sites of plaque rupture.
Methods We performed three-vessel intravascular ultrasound (IVUS) examination in 392 patients; 231 had acute coronary syndrome (ACS) and 161 had stable angina pectoris (SAP). The IVUS detected plaque ruptures in 206 patients: 158 ACS patients and 48 SAP patients. The distance between each coronary plaque rupture segment and the respective coronary ostium was measured with motorized IVUS transducer pullback in all three coronary arteries.
Results There were a total of 273 plaque ruptures in these 206 patients; 143 in the left anterior descending artery (LAD), 40 in the left circumflex artery (LCX), and 90 in the right coronary artery (RCA). There were 67 plaque ruptures in SAP patients and 206 in ACS patients; there were 197 culprit/target lesion plaque ruptures and 76 non-culprit/non-target lesion plaque ruptures. The LAD plaque ruptures were predominantly located between 10 and 40 mm from the LAD ostium (83%, 119 of 143). The LCX plaque ruptures were evenly distributed in the entire LCX tree. Most RCA plaque ruptures were located in segments between 10 and 40 mm (48%, 43 of 90) and in segments >70 mm from the ostium (32%, 29 of 90).
Conclusions Three-vessel IVUS imaging showed that plaque ruptures occurred mainly in proximal segments of the LAD (83% of LAD plaque rupture), the proximal and distal segments of the RCA (48% and 32% of RCA plaque ruptures, respectively), and the entire LCX.
This study was partly supported by the Cardiovascular Research Foundation, Seoul, Korea, and a grant from the Korea Health 21 R&D Project, Ministry of Health and Welfare, Korea (0412-CR02-0704-0001).
- Received October 25, 2004.
- Revision received March 22, 2005.
- Accepted March 29, 2005.
- American College of Cardiology Foundation