Author + information
- Received March 25, 2005
- Revision received May 23, 2005
- Accepted May 31, 2005
- Published online September 20, 2005.
- Shih-Huang Lee, MD⁎,†,§,⁎ (, )
- Ching-Tai Tai, MD⁎,‡,
- Ming-Hsiung Hsieh, MD‡,
- Hsuan-Ming Tsao, MD‡,
- Yenn-Jiang Lin, MD‡,
- Shih-Lin Chang, MD‡,
- Jin-Long Huang, MD⁎,
- Kun-Tai Lee, MD‡,
- Yi-Jen Chen, MD‡,
- Jun-Jack Cheng, MD†,§ and
- Shih-Ann Chen, MD⁎,‡
- ↵⁎Reprint requests and correspondence:
Dr. Shih-Huang Lee, Division of Cardiology, Shin Kong Wu Ho-Su Memorial Hospital, 95 Wen Chang Road, Shih Lin, Taipei, Taiwan, R.O.C
Objectives The purpose of this study was to investigate the predictor of non-pulmonary vein (PV) ectopic beats initiating paroxysmal atrial fibrillation (PAF).
Background Non-PV ectopic beats can initiate PAF in some patients and play an important role in the recurrence of PAF after PV isolation. Information on the predictors of non-PV ectopic beats initiating PAF is unknown.
Methods This study included 293 patients (215 men and 78 women, age 60 ± 14 years) with clinically documented drug-refractory PAF. Of the 94 patients with non-PV ectopic beats initiating PAF, 38 (40%) patients had superior vena cava (SVC) ectopic beats and 32 (34%) had left atrial posterior free wall (LAPFW) ectopic beats.
Results In a univariate analysis, only female gender was related to the presence of non-PV (p = 0.016) and SVC ectopic beats (p = 0.012). Right atrial enlargement (p = 0.005) and left atrial enlargement (p < 0.001) were related to the presence of LAPFW ectopic beats. In a multivariate analysis, female gender (p = 0.043; odds ratio 2.00, 95% confidence interval [CI] 1.02 to 3.92) and left atrial enlargement (p = 0.007; odds ratio 2.34, 95% CI 1.27 to 4.32) could predict the presence of non-PV ectopic beats. Subgroup analysis showed that female gender could predict the presence of SVC ectopic beats (p = 0.039; odds ratio 2.14, 95% CI 1.04 to 4.43). In contrast, left atrial enlargement could predict the presence of LAPFW ectopic beats (p = 0.002; odds ratio 3.89, 95% CI 1.62 to 9.38).
Conclusions The location of non-PV ectopic beats initiating PAF can be predicted by both gender and left atrial enlargement.
This study was supported in part by grants from the National Science Council (NSC 92-2314-B-341-006) and Shin Kong Wu Ho-Su Memorial Hospital (8302-92-0126, SKH-TMU-92-28, SKH-TMU-NSC-93-01), Taipei, Taiwan, R.O.C.
- Received March 25, 2005.
- Revision received May 23, 2005.
- Accepted May 31, 2005.
- American College of Cardiology Foundation