Author + information
- Received March 24, 2005
- Revision received May 28, 2005
- Accepted June 6, 2005
- Published online October 4, 2005.
- Joseph F. Malouf, MD,
- Ravi Kanagala, MD,
- Faisal O. Al Atawi, MD,
- A. Gabriela Rosales, MS,
- Diane E. Davison, MA, RN,
- Narayana S. Murali, MBBS,
- Teresa S.M. Tsang, MD,
- Krishnaswamy Chandrasekaran, MD,
- Naser M. Ammash, MD,
- Paul A. Friedman, MD and
- Virend K. Somers, MD, PhD⁎ ()
- ↵⁎Reprint requests and correspondence:
Dr. Virend K. Somers, Division of Cardiovascular Diseases, Mayo Clinic, 200 First Street SW, Rochester, Minnesota 55905.
Objectives We sought to test the hypothesis that C-reactive protein (CRP) can predict the recurrence of atrial fibrillation (AF) after successful electrical cardioversion (CV).
Background In patients with AF, CRP levels are predictive of immediate failure of CV.
Methods We prospectively measured high-sensitivity CRP in 67 patients with AF or atrial flutter who underwent successful electrical CV.
Results At one-month follow-up, 22 patients (33%) had recurrence of their arrhythmia. Arrhythmia recurrence was associated with significantly higher pre-CV CRP levels (odds ratio [OR] 1.84; 95% confidence interval [CI] 1.14 to 2.98; p = 0.013) even after adjusting for age (OR 2.22; 95% CI 1.25 to 3.93; p = 0.006), for gender (OR 1.89; 95% CI 1.16 to 3.09; p = 0.011), or duration of arrhythmia (OR 1.86; 95% CI 1.13 to 3.07; p = 0.015). On multivariate analysis, CRP was the only independent predictor of arrhythmia recurrence (OR 2.19; 95% CI 1.05 to 4.55; p = 0.036).
Conclusions Our data suggest that high levels of CRP are associated with an increased risk of recurrence of AF within one month. These data support the hypothesis that anti-inflammatory interventions may help in maintenance of normal sinus rhythm after CV. These data also may have implications for the identification of patients who are most likely to experience substantial benefit from CV therapy for AF.
- Received March 24, 2005.
- Revision received May 28, 2005.
- Accepted June 6, 2005.
- American College of Cardiology Foundation