Author + information
- Received April 7, 2005
- Revision received July 26, 2005
- Accepted August 25, 2005
- Published online January 17, 2006.
- Timothy E. Meyer, PhD⁎,†,
- Sándor J. Kovács, PhD, MD†,
- Ali A. Ehsani, MD⁎,†,
- Samuel Klein, MD⁎,
- John O. Holloszy, MD⁎ and
- Luigi Fontana, MD, PhD⁎,‡,⁎ ()
- ↵⁎Reprint requests and correspondence:
Dr. Luigi Fontana, Division of Geriatrics, Washington University School of Medicine, 4566 Scott Avenue, Box 8113, St. Louis, Missouri 63110
Objectives We determined whether caloric restriction (CR) has cardiac-specific effects that attenuate the established aging-associated impairments in diastolic function (DF).
Background Caloric restriction retards the aging process in small mammals; however, no information is available on the effects of long-term CR on human aging. In healthy individuals, Doppler echocardiography has established the pattern of aging-associated DF impairment, whereas little change is observed in systolic function (SF).
Methods Diastolic function was assessed in 25 subjects (age 53 ± 12 years) practicing CR for 6.5 ± 4.6 years and 25 age- and gender-matched control subjects consuming Western diets. Diastolic function was quantified by transmitral flow, Doppler tissue imaging, and model-based image processing (MBIP) of E waves. C-reactive protein (CRP), tumor necrosis factor-alpha (TNF-α), and transforming growth factor-beta1(TGF-β1) were also measured.
Results No difference in SF was observed between groups; however, standard transmitral Doppler flow DF indexes of the CR group were similar to those of younger individuals, and MBIP-based, flow-derived DF indexes, reflecting chamber viscoelasticity and stiffness, were significantly lower than in control subjects. Blood pressure, serum CRP, TNF-α, and TGF-β1levels were significantly lower in the CR group (102 ± 10/61 ± 7 mm Hg, 0.3 ± 0.3 mg/l, 0.8 ± 0.5 pg/ml, 29.4 ± 6.9 ng/ml, respectively) compared with the Western diet group (131 ± 11/83 ± 6 mm Hg, 1.9 ± 2.8 mg/l, 1.5 ± 1.0 pg/ml, 35.4 ± 7.1 ng/ml, respectively).
Conclusions Caloric restriction has cardiac-specific effects that ameliorate aging-associated changes in DF. These beneficial effects on cardiac function might be mediated by the effect of CR on blood pressure, systemic inflammation, and myocardial fibrosis.
Research supported by National Institutes of Health grants HL54179, HL04023 (Dr. Kovács), RR00036 (General Clinical Research Center), DK20579 (Diabetes Research and Training Center), and DK56351 (Clinical Nutrition Research Unit), the Whitaker Foundation (Dr. Kovács), American Heart Association (Dr. Kovács), and the Alan A. and Edith L. Wolff Charitable Trust (Dr. Kovács). Dr. Meyer was supported by Institutional National Research Service Award AG-00078.
- Received April 7, 2005.
- Revision received July 26, 2005.
- Accepted August 25, 2005.
- American College of Cardiology Foundation