Author + information
- Pedro R. Moreno, MD, FACC⁎ ( and )
- Valentin Fuster, MD, PhD, FACC
- ↵⁎Mount Sinai Medical Center, Interventional Cardiology Research, One Gustave Levy Place, Box 1030, New York, New York 10029-6500
The specific commission of our review, titled “The Year in Atherothrombosis,” was to highlight clinically relevant studies in the field published within the last year (1). The letter from Dr. Domı́nguez-Rodriguez and colleagues highlights the importance of the circadian rhythm in the presentation of acute coronary events, a concept established several years ago. The last citation of their letter quotes a study published in 2004, evaluating the light/dark cycle of cytokines and melatonin plasma levels in patients with acute myocardial infarction (AMI) (2). This single, observational, case-control study suggested an association between high levels of interleukin-6 and low levels of melatonin during the dark cycle in patients with AMI. The investigators should be congratulated for their effort. However, the study is not mechanistic, and does not prove causality. Furthermore, the clinical significance of their findings still remains to be elucidated. As a result, in our judgment the study may not meet the criteria to be included as a clinically relevant publication in atherothrombosis in the year 2004.
This LR accomp. LE JACC011705-0202
- American College of Cardiology Foundation