Insights From the NHLBI-Sponsored Women’s Ischemia Syndrome Evaluation (WISE) StudyPart I: Gender Differences in Traditional and Novel Risk Factors, Symptom Evaluation, and Gender-Optimized Diagnostic Strategies
Author + information
- Leslee J. Shaw, PhD⁎,⁎ (leslee.shaw{at}cshs.org),
- C. Noel Bairey Merz, MD⁎,
- Carl J. Pepine, MD§,
- Steven E. Reis, MD†,
- Vera Bittner, MD⁎⁎,
- Sheryl F. Kelsey, PhD‡,
- Marian Olson, MS‡,
- B. Delia Johnson, PhD‡,
- Sunil Mankad, MD∥,
- Barry L. Sharaf, MD¶,
- William J. Rogers, MD⁎⁎,
- Timothy R. Wessel, MD§,
- Christopher B. Arant, MD§,
- Gerald M. Pohost, MD††,
- Amir Lerman, MD‡‡,
- Arshed A. Quyyumi, MD§§,
- George Sopko, MD∥∥,
- WISE Investigators
- ↵⁎Reprint requests and correspondence:
Dr. Leslee J. Shaw, c/o WISE Coordinating Center, University of Pittsburgh, 127 Parran Hall, Graduate School of Public Health, 130 DeSoto Street, Pittsburgh, Pennsylvania 15261.
Abstract
Despite a dramatic decline in mortality over the past three decades, coronary heart disease is the leading cause of death and disability in the U.S. Importantly, recent advances in the field of cardiovascular medicine have not led to significant declines in case fatality rates for women when compared to the dramatic declines realized for men. The current review highlights gender-specific issues in ischemic heart disease presentation, evaluation, and outcomes with a special focus on the results published from the National Institutes of Health-National Heart, Lung, and Blood Institute-sponsored Women’s Ischemia Syndrome Evaluation (WISE) study. We will present recent evidence on traditional and novel risk markers (e.g., high sensitivity C-reactive protein) as well as gender-specific differences in symptoms and diagnostic approaches. An overview of currently available diagnostic test evidence (including exercise electrocardiography and stress echocardiography and single-photon emission computed tomographic imaging) in symptomatic women will be presented as well as data using innovative imaging techniques such as magnetic resonance subendocardial perfusion, and spectroscopic imaging will also be discussed.
Footnotes
This work was supported by contracts from the National Heart, Lung, and Blood Institute, nos. N01-HV-68161, N01-HV-68162, N01-HV-68163, N01-HV-68164, grants U0164829, U01 HL649141, U01 HL649241, a GCRC grant MO1-RR00425 from the National Center for Research Resources, and grants from the Gustavus and Louis Pfeiffer Research Foundation, Denville, New Jersey, Women’s Guild of Cedars-Sinai Medical Center, Los Angeles, California, Ladies Hospital Aid Society of Western Pennsylvania, Pittsburgh, Pennsylvania, and QMED Inc., Laurence Harbor, New Jersey.
- Received September 28, 2004.
- Revision received December 7, 2004.
- Accepted January 4, 2005.
- American College of Cardiology Foundation
