Author + information
- Received June 16, 2005
- Revision received October 15, 2005
- Accepted November 13, 2005
- Published online April 18, 2006.
- ↵⁎Reprint requests and correspondence:
Dr. S. Ward Casscells, Office of Biotechnology, University of Texas Medical School at Houston, 7000 Fannin, UCT 795, Houston, Texas 77030
Up to two-thirds of acute myocardial infarctions develop at sites of culprit lesions without a significant stenosis. New imaging techniques are needed to identify those lesions with an increased risk of developing an acute complication in the near future. Inflammation is a hallmark feature of these vulnerable/high-risk plaques. We have shown that inflamed atherosclerotic plaques are hot and their surface temperature correlates with an increased number of macrophages and decreased fibrous-cap thickness. Multiple animal and human experiments have shown that temperature heterogeneity correlates with arterial inflammation in vivo. Several coronary temperature mapping catheters are currently being developed and studied. These thermography methods can be used in the future to detect vulnerable plaques, potentially to determine patients’ prognosis, and to study the plaque-stabilizing effects of different medications.
↵a Drs. Willerson and Casscells are founders and shareholders in Volcano Therapeutics Inc., a company that develops diagnostic and therapeutic modalities for managing vulnerable plaque.
This work was supported in part by U.S. Department of Defense Grant No. W81XWH-04-2-0035, “Texas Training and Technology for Trauma and Terrorism (T5).” Dr. William A. Zoghbi acted as guest editor.
- Received June 16, 2005.
- Revision received October 15, 2005.
- Accepted November 13, 2005.
- American College of Cardiology Foundation
- High metabolic rate
- Ineffective thermogenesis
- Increased neoangiogenesis
- Thermal heterogeneity of atherosclerotic plaques, ex vivo studies
- Temperature mapping over arterial walls—animal studies
- Effect of blood flow on coronary temperature measurement
- Intracoronary thermal detection—human studies
- Effect of temperature cut point on number of hot plaques
- Intracoronary temperature heterogeneity and systemic inflammation
- Temperature heterogeneity and markers of plaque vulnerability
- Temperature heterogeneity and clinical prognosis
- Clinical implications and future research