Author + information
- Received November 2, 2005
- Revision received February 10, 2006
- Accepted February 21, 2006
- Published online July 4, 2006.
- Timo Baks, MD⁎,†,
- Filippo Cademartiri, MD, PhD⁎,†,
- Amber D. Moelker, MSc⁎,
- Annick C. Weustink, MD†,
- Robert-Jan van Geuns, MD, PhD⁎,†,
- Nico R. Mollet, MD, PhD⁎,†,
- Gabriel P. Krestin, MD, PhD†,
- Dirk J. Duncker, MD, PhD⁎ and
- Pim J. de Feyter, MD, PhD, FACC⁎,†,⁎ ()
- ↵⁎Reprint requests and correspondence:
Dr. Pim J. de Feyter, Department of Cardiology and Radiology, Thorax Center–Room Ba 591, Erasmus Medical Center, Dr. Molewaterplein 40, 3000 GD Rotterdam, the Netherlands.
Objectives We evaluated the accuracy of in vivo delayed-enhancement multislice computed tomography (DE-MSCT) and delayed-enhancement magnetic resonance imaging (DE-MRI) for the assessment of myocardial infarct size using postmortem triphenyltetrazolium chloride (TTC) pathology as standard of reference.
Background The diagnostic value of DE-MSCT for the assessment of acute reperfused myocardial infarction is currently unclear.
Methods In 10 domestic pigs (25 to 30 kg), the circumflex coronary artery was balloon-occluded for 2 h followed by reperfusion. After 5 days (3 to 7 days), DE-MRI (1.5-T) was performed 15 min after administration of 0.2 mmol/kg gadolinium-DTPA using an inversion recovery gradient echo technique. On the same day, DE-MSCT (64-slice) was performed 15 min after administration of 1 gI/kg of iodinated contrast material. One day after imaging, hearts were excised, sectioned in 8 mm short-axis slices, and stained with TTC. Infarct size was defined as the hyperenhanced area on DE-MSCT and DE-MRI images and the TTC-negative area on TTC pathology slices. Infarct size was expressed as percentage of total slice area.
Results Infarct size determined by DE-MSCT and DE-MRI showed a good correlation with infarct size assessed with TTC pathology (R2= 0.96 [p < 0.001] and R2= 0.93 [p < 0.001], respectively). The correlation between DE-MSCT and DE-MRI was also good (R2= 0.96; p < 0.001). The relative difference in CT attenuation value of infarcted myocardium compared to remote myocardium was 191 ± 18%. The relative MR signal intensity between infarcted myocardium and remote myocardium was 554 ± 156%.
Conclusions We demonstrated that DE-MSCT can assess acute reperfused myocardial infarction in good agreement with in vivo DE-MRI and TTC pathology.
- Received November 2, 2005.
- Revision received February 10, 2006.
- Accepted February 21, 2006.
- American College of Cardiology Foundation