Author + information
- Received June 20, 2006
- Revision received August 14, 2006
- Accepted August 14, 2006
- Published online November 21, 2006.
- ↵⁎Reprint requests and correspondence:
Dr. Rong Zhou, Molecular Imaging Laboratories, Department of Radiology, University of Pennsylvania, B6 Blockley Hall, 422 Curie Boulevard, Philadelphia, Pennsylvania 19104.
Stem cell–based cellular cardiomyoplasty represents a promising therapy for myocardial infarction. Noninvasive imaging techniques would allow the evaluation of survival, migration, and differentiation status of implanted stem cells in the same subject over time. This review describes methods for cell visualization using several corresponding noninvasive imaging modalities, including magnetic resonance imaging, positron emission tomography, single-photon emission computed tomography, and bioluminescent imaging. Reporter-based cell visualization is compared with direct cell labeling for short- and long-term cell tracking.
This research was supported by NIH grants R01-NS048315 (to Dr. Acton), R21-EB002473 (to Dr. Zhou), and R01-HL081185 (to Dr. Zhou) and by the Pennsylvania State Department of Health Tobacco Block Grant (to Dr. Zhou).
- Received June 20, 2006.
- Revision received August 14, 2006.
- Accepted August 14, 2006.
- American College of Cardiology Foundation