Author + information
- Received December 2, 2005
- Revision received January 5, 2006
- Accepted February 17, 2006
- Published online July 18, 2006.
- Chris L. Bryson, MD, MS⁎,†,
- Kenneth J. Mukamal, MD, MPH, MA‡,⁎ (, )
- Murray A. Mittleman, DrPH, MD‡,
- Linda P. Fried, MD, MPH§,
- Calvin H. Hirsch, MD∥,
- Dalane W. Kitzman, MD¶ and
- David S. Siscovick, MD, MPH⁎
- ↵⁎Reprint requests and correspondence:
Dr. Kenneth J. Mukamal, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, RO-114, Boston, Massachusetts 02215.
Objectives We investigated the association between alcohol consumption and incident congestive heart failure (CHF) both overall and after adjusting for incident myocardial infarction (MI).
Background Moderate alcohol consumption has been associated with lower risk of CHF and MI.
Methods The Cardiovascular Health study, a prospective cohort study of cardiovascular disease risk factors and outcomes, followed 5,888 subjects ≥65 years old for 7 to 10 years. Cox models were used to estimate the adjusted risk of CHF by reported alcohol consumption.
Results There were 5,595 subjects at baseline at risk for incident CHF with alcohol data and 1,056 events during follow-up. Compared with abstainers, the adjusted risk of CHF was lower among subjects who reported consuming 1 to 6 drinks per week (hazard ratio [HR] 0.82, 95% confidence interval [CI] 0.67 to 1.00, p = 0.05) and 7 to 13 drinks per week (HR 0.66, 95% CI 0.47 to 0.91, p = 0.01). Time-dependent adjustment for incident MI altered only slightly the association between moderate alcohol consumption and CHF (for 1 to 6 drinks per week, HR 0.84, 95% CI 0.65 to 1.04; for 7 to 13 drinks per week, HR 0.69, 95% CI 0.49 to 0.99). Baseline former drinkers had a higher risk of CHF than abstainers (HR 1.51, p < 0.01), but those who quit during the study did not have a higher risk (HR 0.83, 95% CI 0.66 to 1.03).
Conclusions Moderate alcohol use is associated with a lower risk of incident CHF among older adults, even after accounting for incident MI and other factors.
The research reported in this article was supported by contracts N01-HC-85079 through N01-HC-85086, N01-HC-35129, and N01 HC-15103 from the National Heart, Lung, and Blood Institute. Dr. Bryson was a VA HSR&D senior ambulatory care fellow; this material is the result of work supported, in part, with resources from and the use of facilities at VA Puget Sound, Seattle, Washington.
- Received December 2, 2005.
- Revision received January 5, 2006.
- Accepted February 17, 2006.
- American College of Cardiology Foundation