|Invasive/conservative patients, n||1222/1234||76/72||1114/1106||64/67||895/915||203/207||604/596|
|Age, yrs (mean)||66⁎||62||62||66||62||70⁎||62⁎|
|Prior myocardial infarction, %||22||27†||39||26||28||23||23|
|Current smokers, %||30||31||NA||NA||32||21||41|
|Statin at randomization, %||10||21||52‡||43‡||45||NA||27|
|Statin at follow-up, %||55||NA||NA||NA||80||85||92|
|Thienopyridine with PCI, %||100§||NA||NA||100§||96||100¶||100∥|
|Elevated troponin at randomization, %||55||NA||54||100||75||67||100|
|Hours to angiography, median⁎⁎||96/408||48/120††||22/79||6.2/1,464||48/1,020||2.4/86||23/283‡‡|
|Glycoprotein IIb/IIIa inhibitor, type||NA||NA||Tirofiban||NA||NA||Tirofiban||Abciximab|
|Invasive undergoing PCI, %||10||95||94||0||25||100¶||93|
|Conservative undergoing PCI, %||NA||96||59||0||25||100¶||69|
|Conservative not undergoing PCI, %||NA||NA||99||0||0||100¶||0|
|Coronary stent use with PCI, %⁎⁎||62/69||85/85||83/86||44/50||88/90||87/92||88/88|
|Overall PCI or CABG, %⁎⁎||78/45||100/61||64/45||73/39||61/38||78/72||79/54|
|Relative difference in revascularization between treatment arms, %||73||64||42||87||61||8||46|
CABG = coronary artery bypass grafting; NA = not available; PCI = percutaneous coronary intervention.
↵⁎ Median age.
↵† Defined by prior PCI or CABG.
↵‡ Defined as lipid-lowering therapy.
↵§ By protocol, patients who received a stent were treated with a thienopyridine for 1 month.
↵¶ By protocol, patients in both study arms received continuous tirofiban and daily clopidogrel (after a 600-mg loading dose) until PCI, followed by tirofiban for 24 h and clopidogrel for 4 weeks. These agents were discontinued if PCI was not indicated.
↵∥ Patients in both study arms initially received daily clopidogrel (after a 300-mg loading dose). At discharge, clopidogrel was used in 61% of invasively treated patients, and 49% of conservatively treated patients reflecting those who were not revascularized.
↵⁎⁎ Data are formatted as invasive arm/conservative arm.
↵†† Protocol required that patients undergo invasive therapy within these times.
↵‡‡ Median time until PCI, in hours.