Author + information
- Irene Meissner, MD⁎ ()
- ↵⁎Mayo Clinic, Department of Neurology, 200 First Street SW, Rochester, Minnesota 55905
We appreciate and acknowledge the interest in our recently reported study (1). In regard to the comments of Schrale et al., we studied subjects in age increments or “cells” of 10 years beginning at age 45, and we did not find an increased stroke risk in even the younger age cells. A recent case control study published by Petty et al. (2) supports our finding that patent foramen ovale (PFO) does not appear to be a risk factor for cryptogenic stroke in the general population.
Also, Harper and Haqqani provide intriguing thoughts regarding the issue of PFO detection rates in older individuals. It is possible that a PFO may close in older subjects, but this postulate is based on many assumptions, including that older people have elevated left atrial pressures. This is an interesting concept that merits systematic evaluation.
- American College of Cardiology Foundation