Author + information
- Received December 21, 2006
- Revision received February 27, 2007
- Accepted March 13, 2007
- Published online June 19, 2007.
- Willem Drenthen, MD⁎,⁎ (, )
- Petronella G. Pieper, MD, PhD⁎,
- Jolien W. Roos-Hesselink, MD, PhD‡,
- Willem A. van Lottum, MD⁎,
- Adriaan A. Voors, MD, PhD⁎,
- Barbara J.M. Mulder, MD, PhD§,
- Arie P.J. van Dijk, MD, PhD∥,
- Hubert W. Vliegen, MD, PhD¶,
- Sing C. Yap, MD‡,
- Philip Moons, PhD, RN#,
- Tjark Ebels, MD, PhD†,
- Dirk J. van Veldhuisen, MD, PhD, FACC⁎,1,
- ZAHARA Investigators
- ↵⁎Reprint requests and correspondence:
Dr. Willem Drenthen, Department of Cardiology, University Medical Centre Groningen, University of Groningen, P.O. Box 30001, 9700 RB Groningen, the Netherlands.
A search of peer-reviewed literature was conducted to identify reports that provide data on complications associated with pregnancy in women with structural congenital heart disease (CHD). This review describes the outcome of 2,491 pregnancies, including 377 miscarriages (15%) and 114 elective abortions (5%). Important cardiac complications were seen in 11% of the pregnancies. Obstetric complications do not appear to be more prevalent. In complex CHD, premature delivery rates are high, and more children are small for gestational age. The offspring mortality was high throughout the spectrum and was related to the relatively high rate of premature delivery and recurrence of CHD.
↵1 Dr. van Veldhuisen is an established investigator for the Netherlands Heart Foundation (grant D97.017).
Supported by Netherlands Heart Foundation Grant 2002 B125 to Dr. Pieper and by the Interuniversity Cardiology Institute, the Netherlands (ICIN).
- Received December 21, 2006.
- Revision received February 27, 2007.
- Accepted March 13, 2007.
- American College of Cardiology Foundation