|Risk Subset||Year||N||Historical or Measured Risk Factor Data||Univariable RR⁎||Multivariable RR⁎||Model Controlling for Additional Variables Besides That Contained in the FRS:|
|Kondos||2003||8855||Historical||5.8, p= 0.001†||3.9, p= 0.01|
|Greenland||2004||1461||Measured||3.9, p< 0.001||1.3, p< 0.001‡|
|Arad||2005||1293||Measured||26.2, p< 0.0001||NR, p= 0.01||HsCRP|
|Taylor||2005||1639||Measured||NR, p< 0.0001||11.8, p= 0.002||Family history of CHD|
|Vliegenthart||2005||1795||Measured||8.2, p< 0.01||3.2–10.3, p= 0.03||Family history of MI and BMI|
|LaMonte||2005||10 746||Historical||1.6 (men) and 1.3 (women), p< 0.0001||NR§|
BMI = body mass index; CAC = coronary artery calcification; CHD = coronary heart disease; FRS = Framingham Risk Score; HsCRP = high-sensitivity C-reactive protein; MI = myocardial infarction; NR = not reported; RR = relative risk.
↵⁎ For RR, a linear trend is presented if not indicated otherwise. Kondos: for any detectable CAC in men only; Greenland: for CAC greater than 300 versus CAC = 0 for univariable RR, evaluated as a continuous measure in the multivariable model; Arad: univariable RR is for score greater than or equal to 400, multivariable RR was NR; Taylor: univariable RR was NR, multivariable risk ratio is in men only and for any CAC score versus CAC = 0; Vliegenthart: multivariable is across a range of CAC from 101 to greater than 1000; LaMonte: risk factors measured in a clinical subset of 3619 subjects; univariable reported separately for men (1.6) and women (1.3), multivariable RR were NR but stated to be similar to age-adjusted models.
↵† For men only.
↵‡ For intermediate to high FRS.
↵§ pfor risk adjustment was not specified but noted as significant.