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Kern MJ. Attenuated Coronary Collateral Function After Drug-Eluting Stent Implantation (editorial comment). J Am Coll Cardiol 2007;49:21–2.
The following section should have been stated as follows. The author apologizes for this error.
Why would the drugs on DES have an influence on collateral function?Sirolimus (Rapamycin) and Taxol (Paclitaxel) are both potent immunosuppressant and antiproliferative drugs. Paclitaxel binds to cellular microtubules inhibiting the depolymerization into tubulin, blocking cellular mitosis and proliferation. Sirolimus acts by binding to the cytosolic protein FK-binding protein 12 (FKBP12). The sirolimus-FKBP12 complex does not effect calcineurin but rather inhibits the mammalian target of rapamycin (mTOR) pathway through derepression of PP2A, inhibiting lymphocyte proliferation, and responses to IL-2 as well as blocking the activation of T- and B-cells. Some of these mechanisms likely impact either the stimuli to or direct response of collateral angiogenesis (6,10).
- American College of Cardiology Foundation