Author + information
- Received May 14, 1984
- Revision received July 9, 1984
- Accepted July 25, 1984
- Published online January 1, 1985.
- ↵*Address for reprints: Delon Wu, MD, Chang Gung Memorial Hospital, 199 Tung-Hwa North Road, Taipei, Taiwan, Republic of China.
Electrophysiologic studies were performed in two patients. In one patient (Case 1) with ventricular pre-excitation and paroxysmal supraventricular tachycardia, studies after diltiazem administration showed two QRS responses to a single atrial stimulus during atrial pacing at a cycle length of 300 ms. The first QRS response with full pre-excitation and short PR interval was consistent with accessory pathway conduction, while the second QRS response with a normal duration and an atrio-His bundle interval of 350 ms was consistent with normal pathway conduction. The second QRS response was followed by initiation of supraventricular tachycardia. Studies after verapamil administration on a separate day disclosed two atrial responses to a single QRS complex during ventricular pacing at cycle lengths between 330 and 280 ms, suggesting simultaneous retrograde accessory and normal pathway conduction.
In Case 2 with a supraventricular tachycardia using a fast atrioventricular nodal pathway for anterograde and a slow ventriculoatrial pathway for retrograde conduction, two atrial responses to a single QRS complex were observed during ventricular pacing at cycle lengths between 500 and 400 ms. The first atrial response showed a stimulus to atrial interval of 120 ms and an atrial activation sequence with the low septal right atrium being earlier than other atrial sites, suggesting retrograde fast pathway conduction. The second atrial response showed a stimulus to atrial interval of 505 ms and an atrial activation sequence with low septal right atrium being simultaneous with the proximal coronary sinus, suggesting retrograde slow pathway conduction. Thus, double atrial responses to a single QRS complex may result from simultaneous conduction through two retrograde pathways when pacing induced conduction delay in the slower pathway is sufficient to allow recovery of the atria to respond to the second slower retrograde impulse.
- Received May 14, 1984.
- Revision received July 9, 1984.
- Accepted July 25, 1984.
- American College of Cardiology Foundation