Author + information
- Received June 6, 1984
- Revision received October 16, 1984
- Accepted November 5, 1984
- Published online March 1, 1985.
- ↵*Address for reprints: Joachim Schofer, MD, Department of Cardiology, University Hospital Eppendorf, Martinistrasse 52, 2000 Hamburg 20, West Germany.
To assess whether the absence of new thallium-201 uptake after successful intracoronary thrombolysis reflects a disturbance of myocardial cell function or lack of capillary reperfusion, dual isotope scintigraphic studies with thallium-201 and technetium-99m micro-albumin aggregates were performed in 16 patients with acute anterior myocardial infarction. Intracoronary thallium-201 and technetium-99m scintigraphy performed before intracoronary thrombolysis in 12 of the 16 patients resulted in identical thallium-201 and technetium-99m defect sizes.
Immediately after intracoronary thrombolysis, thallium-201 and technetium-99m scintigraphy was repeated in 11 of the 12 patients. In 4 of the 11, the initial thallium and technetium scintigraphic defects were significantly reduced, and in 6 of the 11, they were only slightly reduced; there was no difference in the size of the residual defect as assessed with both radionuclides in all 10 of the 11 patients. In the eleventh patient, there was a significant reduction of the initial technetium-99m scintigraphic defect but no change in the size of the thallium-201 defect. In four other patients, scintigrams were obtained only after intracoronary thrombolysis; these revealed no difference in thallium-201 and technetium-99m defect size.
In seven of eight patients restudied 2 to 4 weeks after intracoronary thrombolysis, thallium-201 and technetium-99m defect sizes were identical with those immediately after intracoronary thrombolysis; in the eighth patient there was no difference in thallium-201 and tech-netium-99m defect size, although such a difference had been present immediately after intracoronary thrombolysis. These results show that the absence of new thallium-201 uptake after successful intracoronary thrombolysis reflects lack of capillary reperfusion, suggesting that the “no reflow” phenomenon occurs in human beings.
- Received June 6, 1984.
- Revision received October 16, 1984.
- Accepted November 5, 1984.
- American College of Cardiology Foundation