Author + information
- Received April 20, 2007
- Revision received May 11, 2007
- Accepted May 23, 2007
- Published online September 4, 2007.
- ↵⁎Reprint requests and correspondence:
Dr. Geoffrey S. Ginsburg, Duke Institute for Genome Sciences and Policy, Box 3382, Durham, North Carolina 27710.
Genetic information is beginning to have a direct impact on patient care and it is important that cardiologists appreciate the value and approaches to associating genetic variation and health outcomes. Genetic associations should be based on compelling genetic and biological hypotheses and should be statistically sound so as to reduce the possibility of “false discovery” in the setting of testing multiple hypotheses. Study designs should clearly define cases and controls and measurement of phenotypes. Finally, findings should be replicated in at least 1 independent cohort. Consideration of these principles should provide insight into disease biology based on genetic findings and encourage their meaningful adoption into clinical practice.
- Received April 20, 2007.
- Revision received May 11, 2007.
- Accepted May 23, 2007.
- American College of Cardiology Foundation
- Association studies should be based on a compelling genetic hypothesis
- Association studies should provide a clear rationale for selection of SNPs for study
- Association studies should provide a solid biological foundation for the findings
- There is a need to reduce the possibility of “false discovery” in the setting of testing multiple hypotheses
- Findings should be replicated in at least 1 independent cohort
- When are negative results important?
- Study designs should be clear on the selection of cases and controls or cohorts, definition and measurement of the phenotype, and acknowledgment of potential biases and confounding