Author + information
- Received December 12, 2006
- Revision received April 20, 2007
- Accepted April 23, 2007
- Published online August 21, 2007.
- Gregg C. Fonarow, MD, FACC⁎,⁎ (, )
- Wendy Gattis Stough, PharmD†,
- William T. Abraham, MD, FACC‡,
- Nancy M. Albert, PhD, RN§,
- Mihai Gheorghiade, MD, FACC∥,
- Barry H. Greenberg, MD, FACC¶,
- Christopher M. O’Connor, MD, FACC#,
- Jie Lena Sun, MS⁎⁎,
- Clyde W. Yancy, MD, FACC††,
- James B. Young, MD, FACC‡‡,
- OPTIMIZE-HF Investigators and Hospitals
- ↵⁎Reprint requests and correspondence:
Dr. Gregg C. Fonarow, Ahmanson-UCLA Cardiomyopathy Center, UCLA Medical Center, 10833 LeConte Avenue, Room 47-123 CHS, Los Angeles, California 90095-1679.
Objectives We sought to evaluate the characteristics, treatments, and outcomes of patients with preserved and reduced systolic function heart failure (HF).
Background Heart failure with preserved systolic function (PSF) is common but not well understood.
Methods This analysis of the OPTIMIZE-HF (Organized Program to Initiate Lifesaving Treatment in Hospitalized Patients With Heart Failure) registry compared 20,118 patients with left ventricular systolic dysfunction (LVSD) and 21,149 patients with PSF (left ventricular ejection fraction [EF] ≥40%). Sixty- to 90-day follow-up was obtained in a pre-specified 10% sample of patients. Analyses of patients with PSF defined as EF >50% were also performed for comparison.
Results Patients with PSF (EF ≥40%) were more likely to be older, female, and Caucasian and to have a nonischemic etiology. Although length of hospital stay was the same in both groups, risk of in-hospital mortality was lower in patients with PSF (EF ≥40%) (2.9% vs. 3.9%; p < 0.0001). During 60- to 90-day post-discharge follow-up, patients with PSF (EF ≥40%) had a similar mortality risk (9.5% vs. 9.8%; p = 0.459) and rehospitalization rates (29.2% vs. 29.9%; p = 0.591) compared with patients with LVSD. Findings were comparable with those with PSF defined as EF >50%. In a risk- and propensity-adjusted model, there were no significant relationships between discharge use of angiotensin-converting enzyme inhibitor/angiotensin receptor blocker or beta-blocker and 60- to 90-day mortality and rehospitalization rates in patients with PSF.
Conclusions Data from the OPTIMIZE-HF registry reveal a high prevalence of HF with PSF, and these patients have a similar post-discharge mortality risk and equally high rates of rehospitalization as patients with HF and LVSD. Despite the burden to patients and health care systems, data are lacking on effective management strategies for patients with HF and PSF. (Organized Program To Initiate Lifesaving Treatment In Hospitalized Patients With Heart Failure [OPTIMIZE-HF]); http://www.clinicaltrials.gov/ct/show/NCT00344513?order=1; NCT00344513)
GlaxoSmithKline funded both the OPTIMIZE-HF registry and this analysis of registry data. Author disclosures are provided at the end of this article. Ileana Piña, MD, FACC, served as Guest Editor for this article. See accompanying online Cardiosource Slide Set.
- Received December 12, 2006.
- Revision received April 20, 2007.
- Accepted April 23, 2007.
- American College of Cardiology Foundation