Author + information
- Received January 11, 2008
- Revision received June 27, 2008
- Accepted August 13, 2008
- Published online November 18, 2008.
- ↵⁎Reprint requests and correspondence:
Dr. Raymond L. Benza, Allegheny General Hospital, 320 East North Avenue, 16th Floor, South Tower, Pittsburgh, Pennsylvania 15212
Pulmonary arterial hypertension (PAH) is a progressive disorder characterized by abnormally elevated blood pressure of the pulmonary circulation that results, over time, from extensive vascular remodeling and increased pulmonary vascular resistance. Recent advances in magnetic resonance imaging (MRI) technology have led to the development of techniques for noninvasive assessment of cardiovascular structure and function, including hemodynamic parameters in the pulmonary circulation, which are superior in their identification of right ventricular morphologic changes. These advantages make cardiac MRI an attractive modality for following up and providing prognoses in patients with PAH. In this review, we summarize recent developments in the use of MRI for the diagnosis, assessment, and ongoing monitoring of patients with PAH. Over the coming decade, it can be anticipated that continued improvements in MRI image acquisition, spatial and temporal resolution, and analytical techniques will result in improved understanding of PAH pathophysiology, diagnosis, and prognostic variables, and will supplement, and may even replace, some of the invasive procedures currently applied routinely to the evaluation of PAH.
Supported by a grant from Actelion Pharmaceuticals. Dr. Benza received honoraria from Actelion, Encysive, and Pfizer.
- Received January 11, 2008.
- Revision received June 27, 2008.
- Accepted August 13, 2008.
- American College of Cardiology Foundation