Author + information
- Oliver J. Rider, BM, BCh,
- Jane M. Francis, DCR, DNM,
- Mohammed K. Ali, MSc,
- Steffen E. Petersen, MD, DPhil,
- Monique Robinson, MSc, MBChB, DPhil,
- Matthew D. Robson, PhD,
- James P. Byrne, MBChB, MD,
- Kieran Clarke, PhD and
- Stefan Neubauer, MD* ()
- ↵*Department of Cardiovascular Medicine, John Radcliffe Hospital, Oxford, OX3 9DU, United Kingdom
We are pleased that Dr. Taegtmeyer and colleagues found our report of interest (1). We recognize that the beneficial changes in cardiovascular function and metabolism that were seen to follow bariatric surgery in the study conducted by the Texas group were similar to those seen in our study, and they occurred at an earlier time point. The changes in our study occurred in the absence of significant cardiovascular risk factors, including insulin resistance, whereas the Texas group study enrolled consecutive patients undergoing bariatric surgery (2). Both studies underscore the potential importance of leptin in the regulation of cardiovascular function and cardiac hypertrophy. Clearly, the concept proposed in the letter (i.e., that the effects of weight loss surgery on cardiac function and systemic metabolism are either hormonally or centrally regulated) is an interesting one that merits further evaluation. Although the Texas group have shown very early changes, we are currently seeking to gain further insight into the long-term regulation of the cardiovascular system by examining the changes in cardiovascular function after a more prolonged weight loss of several years and the effects of weight re-gain in individuals unable to keep their body mass index low.
Please note: This work has won the 2008 American Heart Association Nutrition, Physical Activity and Metabolism Young Investigator Award.
- American College of Cardiology Foundation