Author + information
- Heinrich Taegtmeyer, MD, DPhil* (, )
- Joshua G. Leichman, MD,
- Manuel Reyes, MD and
- Thomas R. Lux, MD
- ↵*Department of Internal Medicine, Division of Cardiology, University of Texas Houston Medical School, 6431 Fannin, Room MSB 1.246, Houston, Texas 77030
The carefully conducted study by the Oxford group (1) reports beneficial effects of weight loss after 2 nonpharmacological interventions, diet or bariatric surgery. In case of the latter, we have made similar observations except at a much earlier time point (2). Three months after bariatric surgery for clinically severe obesity (body mass index 47 kg/m2), visceral fat mass (but not subcutaneous fat), glucose homeostasis, and left ventricular diastolic function had already normalized (2). More importantly, there was a dramatic decline in serum leptin levels, a decrease in muscle fat, and a massive decrease in transcript levels of enzymes in the pathway of muscle lipid partitioning (3). Our observations, together with those of Rider et al. (1), suggest that the effects of weight-loss surgery on cardiac function and systemic metabolism are either hormonally or centrally regulated.
- American College of Cardiology Foundation