Duration (Ref. #)
1 year (53)
|Little et al.|
Losartan vs. HCTZ
6 months (55)
Valsartan + RR ↓ vs. RR ↓
38 weeks (56)
|HF signs and symptoms (other criteria)||Absent (prior MI)||Absent (exertional HTN)||Absent (HTN)|
|Normal LV systolic function||LVEF >40%||LVEF >50%||LVEF >50%|
|LV diastolic dysfunction||—||E/A <1.0||E′ <8|
Enrollment criteria of small mechanistic trials in patients with prior myocardial infarction (MI) or with arterial hypertension (HTN), who had normal LVEF and no HF.
RR ↓ = regular blood pressure lowering therapy; other abbreviations as in Table 1.