Journal of the American College of Cardiology
Volume 55, Issue 7, February 2010 DOI: 10.1016/j.jacc.2009.07.072
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Coronary Artery Disease

The Absence of Coronary Calcification Does Not Exclude Obstructive Coronary Artery Disease or the Need for Revascularization in Patients Referred for Conventional Coronary Angiography

Ilan Gottlieb, Julie M. Miller, Armin Arbab-Zadeh, Marc Dewey, Melvin E. Clouse, Leonardo Sara, Hiroyuki Niinuma, David E. Bush, Narinder Paul, Andrea L. Vavere, John Texter, Jeffery Brinker, João A.C. Lima and Carlos E. Rochitte

Table 1

Table 1

Baseline Characteristics

Calcium Score
0 (n = 72)1–10 (n = 24)>10 (n = 195)p Value
Age, yrs55.9 ± 9.960.1 ± 9.560.5 ± 9.90.003
Men43 (60)16 (67)154 (79)0.005
Race0.014
 White41 (57)18 (75)137 (70)
 Black11 (15)1 (4)6 (3)
 Asian16 (22)5 (21)45 (23)
 Other4 (6)07 (4)
BMI, kg/m2*27 ± 4.828 ± 4.728 ± 4.30.55
Hypertension43 (60)16 (67)133 (68)0.43
Diabetes mellitus12 (17)3 (13)53 (27)0.083
Dyslipidemia35 (49)14 (58)126 (65)0.059
Smoking0.048
 Current15 (21)3 (13)38 (19)
 Past22 (31)7 (29)90 (46)
 Never35 (49)14 (58)67 (34)
Family history of CAD16 (22)4 (17)74 (25)0.39
Chest pain (within 30 days)38 (53)11 (48)120 (62)0.25
ED presentation†16 (22)12 (50)61 (31)0.035
Presence of any ≥50% stenosis‡14 (19)11 (46)138 (71)<0.001
Disease distribution by CCA‡<0.001
 No disease56 (78)11 (46)53 (27)
 Single-vessel disease14 (19)10 (42)49 (25)
 2-vessel disease2 (3)3 (13)61 (31)
 3-vessel disease0032 (16)
Revascularization in 30 days9 (13)6 (25)85 (44)<0.001

Values are mean ± SD or n (%).

BMI = body mass index; CAD = coronary artery disease.

  • ↵* Calculated as weight in kilograms divided by height in meters squared.

  • ↵† Patients referred for angiography from the emergency department (ED).

  • ↵‡ Defined by quantitative conventional coronary angiography (CCA).

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