Author + information
- Samuel Siu, MD* ( and )
- Nikolaos Tzemos, MD
- ↵*Department of Medicine, University of Western Ontario, C6-005, University Hospital, 339 Windermere Road, London, Ontario N6A 5A5, Canada
We are grateful to Drs. Opotowsky and Landzberg for raising an important question such as the impact of bicuspid aortic valve (BAV) morphology on aortic dilation, aortic stiffness, serum matrix metalloproteinase levels, and endothelial function in our study (1). Regrettably, our study was not designed to examine the role of BAV morphology, and it would be inappropriate to perform additional post hoc analyses, particularly in view of the small sample size. Nevertheless, the equal proportion of patients with anteroposterior aortic leaflets orientation within the 2 BAV study groups probably eliminated the confounding effect of bicuspid valve morphology on the observed difference in aortic stiffness, serum matrix metalloproteinase, and endothelial function between the BAV patients with and those without ascending aortic dilation (1).
- American College of Cardiology Foundation