Author + information
- Received June 17, 2009
- Revision received January 7, 2010
- Accepted February 8, 2010
- Published online August 10, 2010.
- Amit R. Patel, MD*,
- Patrick F. Antkowiak, BS†,
- Kiran R. Nandalur, MD∥,
- Amy M. West, MD‡,
- Michael Salerno, MD, PhD‡,
- Vishal Arora, MD¶,
- John Christopher, RT§,
- Frederick H. Epstein, PhD†,§ and
- Christopher M. Kramer, MD‡,§,* ()
- ↵*Reprint requests and correspondence:
Dr. Christopher M. Kramer, University of Virginia Health System, Departments of Medicine and Radiology, 1215 Lee Street, Box 800170, Charlottesville, Virginia 22908
Objectives The purpose of this paper was to compare quantitative cardiac magnetic resonance (CMR) first-pass contrast-enhanced perfusion imaging to qualitative interpretation for determining the presence and severity of coronary artery disease (CAD).
Background Adenosine CMR can detect CAD by measuring perfusion reserve (PR) or by qualitative interpretation (QI).
Methods Forty-one patients with an abnormal nuclear stress scheduled for X-ray angiography underwent dual-bolus adenosine CMR. Segmental myocardial perfusion analyzed using both QI and PR by Fermi function deconvolution was compared to quantitative coronary angiography.
Results In the 30 patients with complete quantitative data, PR (mean ± SD) decreased stepwise as coronary artery stenosis (CAS) severity increased: 2.42 ± 0.94 for <50%, 2.14 ± 0.87 for 50% to 70%, and 1.85 ± 0.77 for >70% (p < 0.001). The PR and QI had similar diagnostic accuracies for detection of CAS >50% (83% vs. 80%), and CAS >70% (77% vs. 67%). Agreement between observers was higher for quantitative analysis than for qualitative analysis. Using PR, patients with triple-vessel CAD had a higher burden of detectable ischemia than patients with single-vessel CAD (60% vs. 25%; p = 0.02), whereas no difference was detected by QI (31% vs. 21%; p = 0.26). In segments with myocardial scar (n = 64), PR was 3.10 ± 1.34 for patients with CAS <50% (n = 18) and 1.91 ± 0.96 for CAS >50% (p < 0.0001).
Conclusions Quantitative PR by CMR differentiates moderate from severe stenoses in patients with known or suspected CAD. The PR analysis differentiates triple- from single-vessel CAD, whereas QI does not, and determines the severity of CAS subtending myocardial scar. This has important implications for assessment of prognosis and therapeutic decision making.
This study was supported in part by research grants from Astellas Pharma US Inc., Siemens Medical Solutions, and 5-T32 EB003841. Dr. Patel has received a research grant from Astellas Pharma. Dr. Epstein has received research support from Siemens Medical Solutions. Dr. Kramer has received research equipment support from Siemens Medical Solutionsand a research grant from Astellas Pharma. Mr. Antkowiak and Drs. Nandalur, West, Salerno, Arora, and Christopher have reported that they have no relationships to disclose. Drs. Patel, Antkowiak, Epstein, and Kramer contributed equally to this work.
- Received June 17, 2009.
- Revision received January 7, 2010.
- Accepted February 8, 2010.
- American College of Cardiology Foundation