Author + information
- John J.V. McMurray, MD⁎ ()
- ↵⁎British Heart Foundation Cardiovascular Research Centre, University of Glasgow, 126 University Place, Glasgow G12 8TA, United Kingdom
Plasma coenzyme Q10 (CoQ10) concentration was not an independent predictor of any major clinical outcome in the elderly patients with quite advanced heart failure in CORONA (Controlled Rosuvastatin Multinational Study in Heart Failure) (1). Looking at the outcomes that should be most sensitive to any harmful effect of lowering CoQ10, there was no convincing effect of rosuvastatin on either the risk for heart failure hospitalization or the composite of death or heart failure hospitalization. Prior studies of CoQ10 supplementation in heart failure have not shown any convincing benefit. Although it would be of interest to study a statin with and without CoQ10 supplementation, such a trial is very unlikely to be conducted.
- American College of Cardiology Foundation