Author + information
- Received May 18, 2010
- Revision received July 26, 2010
- Accepted August 10, 2010
- Published online January 25, 2011.
- Satoru Kodama, MD, PhD⁎,
- Kazumi Saito, MD, PhD⁎,
- Shiro Tanaka, PhD†,
- Chika Horikawa, RD⁎,
- Aki Saito, RD⁎,
- Yoriko Heianza, RD⁎,
- Yui Anasako, RD⁎,
- Yukako Nishigaki, RD⁎,
- Yoko Yachi, MS⁎,
- Kaoruko Tada Iida, MD, PhD⁎,
- Yasuo Ohashi, PhD‡,
- Nobuhiro Yamada, MD, PhD⁎ and
- Hirohito Sone, MD, PhD⁎,⁎ ()
- ↵⁎Reprint requests and correspondence:
Dr. Hirohito Sone, Professor, Department of Internal Medicine, University of Tsukuba Institute of Clinical Medicine, 3-2-7 Miya-machi, Mito, Ibaraki 310-0015, Japan
Objectives The purpose of this meta-analysis is to summarize the estimated risk of atrial fibrillation (AF) related to alcohol consumption.
Background Results from observational studies examining the relationship between alcohol consumption and AF are inconsistent.
Methods A systematic electronic search of Medline (January 1966 to December 2009) and Embase (January 1974 to December 2009) databases was conducted for studies using key words related to alcohol and AF. Studies were included if data on effect measures for AF associated with habitual alcohol intake were reported or could be calculated. The effect measures for AF for the highest versus lowest alcohol intake in individual studies were pooled with a variance-based method. Linear and spline regression analyses were conducted to quantify the relationship between alcohol intake and AF risk.
Results Fourteen eligible studies were included in this meta-analysis. The pooled estimate of AF for the highest versus the lowest alcohol intake was 1.51 (95% confidence interval: 1.31 to 1.74). A linear regression model showed that the pooled estimate for an increment of 10 g per day alcohol intake was 1.08 (95% confidence interval: 1.05 to 1.10; R2 = 0.43, p < 0.001). A spline regression model also indicated that the AF risk increased with increasing levels of alcohol consumption.
Conclusions Results of this meta-analysis suggest that not consuming alcohol is most favorable in terms of AF risk reduction.
Drs. Sone and Kodama are recipients of a Grant-in-Aid for Scientific Research (20300227) and Postdoctoral Research Fellowship (202965), respectively, both from the Japan Society for the Promotion of Science. This work is also financially supported by the Japan Cardiovascular Research Foundation and Ministry of Health, Labor, and Welfare, Japan. The sponsors had no influence over the design and conduct of the study; collection, management, analysis, and interpretation of the data; or preparation, review, or approval of the manuscript. The authors have reported that they have no relationships to disclose.
- Received May 18, 2010.
- Revision received July 26, 2010.
- Accepted August 10, 2010.
- American College of Cardiology Foundation