Author + information
- Samuel C. Siu, MD, SM⁎ ( and )
- Candice K. Silversides, MD, SM
- ↵⁎Schulich School of Medicine and Dentistry, University of Western Ontario, Room C6-005, University Hospital London Health Sciences Centre, 339 Windermere Road, London, Ontario N6A 5A5, Canada
The authors thank Dr. Nemes and colleagues for their interest in our paper (1) and for highlighting the association between bicuspid aortic valve disease and abnormal elasticity of the aortic root and ascending aorta. We agree that bicuspid aortic valve disease is a disease of the aorta and that this abnormality includes intrinsic abnormalities in the elastic properties of the aorta. The role of these findings in the management of patients with bicuspid aortic valve remains to be defined and will require further prospective investigations.
We also thank Dr. Martín and colleagues for sharing their data on genetic variation in the transforming growth factor beta receptor type II (TGFBR2) gene in 2 patients with bicuspid aortic valve disease. Bicuspid aortic valve disease is likely due to different genes with different patterns of inheritance. Hopefully, with work from their group and others, the role of TGFBR2 and other genes that affect the susceptibility of patients with bicuspid aortic disease to valvular and/or thoracic aortic disease will be defined.
- American College of Cardiology Foundation