Author + information
- Received April 20, 2011
- Revision received June 21, 2011
- Accepted June 27, 2011
- Published online November 1, 2011.
- Bon-Kwon Koo, MD, PhD⁎,
- Andrejs Erglis, MD, PhD†,
- Joon-Hyung Doh, MD, PhD‡,
- David V. Daniels, MD§,
- Sanda Jegere, MD∥,
- Hyo-Soo Kim, MD, PhD⁎,
- Allison Dunning, MD¶,
- Tony DeFrance, MD#,
- Alexandra Lansky, MD⁎⁎,
- Jonathan Leipsic, BSc, MD†† and
- James K. Min, MD‡‡,⁎ ()
- ↵⁎Reprint requests and correspondence:
Dr. James K. Min, Division of Cardiology, Department of Medicine, Cedars-Sinai Medical Center, 8700 Beverly Boulevard, South Taper Building 1258, Los Angeles, California 90048
Objectives The aim of this study was to determine the diagnostic performance of a new method for quantifying fractional flow reserve (FFR) with computational fluid dynamics (CFD) applied to coronary computed tomography angiography (CCTA) data in patients with suspected or known coronary artery disease (CAD).
Background Measurement of FFR during invasive coronary angiography is the gold standard for identifying coronary artery lesions that cause ischemia and improves clinical decision-making for revascularization. Computation of FFR from CCTA data (FFRCT) provides a noninvasive method for identifying ischemia-causing stenosis; however, the diagnostic performance of this new method is unknown.
Methods Computation of FFR from CCTA data was performed on 159 vessels in 103 patients undergoing CCTA, invasive coronary angiography, and FFR. Independent core laboratories determined FFRCT and CAD stenosis severity by CCTA. Ischemia was defined by an FFRCT and FFR ≤0.80, and anatomically obstructive CAD was defined as a CCTA with stenosis ≥50%. Diagnostic performance of FFRCT and CCTA stenosis was assessed with invasive FFR as the reference standard.
Results Fifty-six percent of patients had ≥1 vessel with FFR ≤0.80. On a per-vessel basis, the accuracy, sensitivity, specificity, positive predictive value, and negative predictive value were 84.3%, 87.9%, 82.2%, 73.9%, 92.2%, respectively, for FFRCT and were 58.5%, 91.4%, 39.6%, 46.5%, 88.9%, respectively, for CCTA stenosis. The area under the receiver-operator characteristics curve was 0.90 for FFRCT and 0.75 for CCTA (p = 0.001). The FFRCT and FFR were well correlated (r = 0.717, p < 0.001) with a slight underestimation by FFRCT (0.022 ± 0.116, p = 0.016).
Conclusions Noninvasive FFR derived from CCTA is a novel method with high diagnostic performance for the detection and exclusion of coronary lesions that cause ischemia. (The Diagnosis of ISChemia-Causing Stenoses Obtained Via NoninvasivE FRactional FLOW Reserve; NCT01189331)
Dr. DeFrance is on the Speaker's Bureau of Toshiba Medical Systems. Dr. Leipsic is on the Speaker's Bureau and medical advisory board of GE Healthcare. All other authors have reported that they have no relationships relevant to the contents of this paper to disclose.
- Received April 20, 2011.
- Revision received June 21, 2011.
- Accepted June 27, 2011.
- American College of Cardiology Foundation