|Population-Based Cohort Studies||Randomized Clinical Trials|
|Discover potential environmental, behavioral, and biological factors in relation to CVD||Test new interventions on environmental, behavioral, and biological factors to prevent CVD|
|Identify novel risk factors that contribute independently to CVD||Determine optimal level of risk-factor management to prevent CVD|
|Establish CVD risk-prediction algorithms||Test new interventions to treat established CVD|
|Discover potential genetic influences on drug response||Test genetic influences on drug response|
|Identify interactive effects of biological, genetic, and environmental factors on CVD||Compare treatments to identify optimal therapies for CVD|
|Quantify burden and disparity of CVD in populations||Test effectiveness of new diagnostic or screening modalities|
CVD = cardiovascular disease.