Journal of the American College of Cardiology

Volume 58, Issue 23, November 2011 DOI: 10.1016/j.jacc.2011.08.035
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The Associations of Fetuin-A With Subclinical Cardiovascular Disease in Community-Dwelling Persons
The Rancho Bernardo Study

Joachim H. Ix, Elizabeth Barrett-Connor, Christina L. Wassel, Kevin Cummins, Jaclyn Bergstrom, Lori B. Daniels and Gail A. Laughlin

Table 1

Table 1

Baseline Characteristics of Community-Living Individuals by Quartiles of Plasma Fetuin-A: The Rancho Bernardo Study

All (n = 1,375)Fetuin-A Quartiles, Fetuin-A Range (g/l)p Value*
I <0.45 (n = 342)II 0.45–0.51 (n = 343)III 0.52–0.58 (n = 345)IV ≥0.59 (n = 345)
Demographic data
 Age (yrs)70 ± 1173 ± 1270 ± 1169 ± 1168 ± 11<0.001
 Male492 (36%)138 (40%)132 (38%)133 (39%)89 (26%)<0.001
Lifestyle factors
 Current smoking107 (8%)28 (8%)30 (9%)21 (6%)28 (8%)0.58
 Regular physical exercise979 (71%)243 (71%)261 (76%)243 (70%)232 (67%)0.08
 Alcohol ≥3 drinks/week626 (46%)178 (52%)165 (48%)155 (45%)128 (37%)0.001
Health status
 Oral estrogen use†350 (25%)53 (26%)75 (36%)81 (38%)141 (55%)<0.001
 Fair or poor health status83 (6%)27 (8%)21 (6%)18 (5%)17 (5%)0.34
 Any hospital stays in past yr106 (8%)25 (8%)27 (8%)28 (8%)26 (8%)0.98
 Comorbidities1 (0–2)1 (0–2)1 (0–2)1 (0–2)1 (0–2)0.29
 Medications1 (1–1)1 (1–1)1 (1–1)1 (1–1)1 (1–1)0.91
Comorbidities
 Obese161 (12%)23 (7%)41 (12%)50 (14%)47 (14%)0.01
 Diabetes170 (12%)35 (10%)37 (11%)40 (12%)58 (17%)0.03
 Hypertension674 (49%)171 (50%)155 (45%)171 (50%)177 (51%)0.41
Cardiovascular risk factors
 Body mass index (kg/m2)25 ± 425 ± 426 ± 426 ± 426 ± 4<0.001
 Systolic blood pressure (mm Hg)135 ± 22134 ± 21134 ± 22135 ± 24135 ± 210.94
 Diastolic blood pressure (mm Hg)76 ± 975 ± 1076 ± 977 ± 977 ± 90.03
 Total cholesterol (mg/dl)211 ± 35205 ± 34209 ± 36212 ± 35217 ± 36<0.001
 LDL cholesterol (mg/dl)128 ± 32122 ± 32128 ± 32130 ± 32130 ± 310.05
 HDL cholesterol (mg/dl)59 ± 1761 ± 1759 ± 1658 ± 1759 ± 180.18
 Triglycerides (mg/dl)103 (73–146)90 (67–121)96 (67–139)110 (76–156)123 (85–187)<0.001
 eGFR (ml/min/1.73 m2)68 ± 1668 ± 1668 ± 1469 ± 1868 ± 140.48
 eGFR <60 ml/min/1.73 m2413 (30%)104 (30%)105 (31%)104 (30%)1060 (29%)0.97

Values are mean ± SD, n (%), or median (interquartile range).

eGFR = estimated glomerular filtration rate; HDL = high-density lipoprotein; LDL = low-density lipoprotein.

  • ↵* p value across quartiles by analysis of variance, chi-square unless otherwise indicated.

  • ↵† Women only. p value obtained by Kruskal-Wallis test.

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