Author + information
- Received April 14, 2011
- Revision received July 26, 2011
- Accepted August 2, 2011
- Published online January 10, 2012.
- Stefan Toggweiler, MD⁎,
- Ronen Gurvitch, MBBS⁎,
- Jonathon Leipsic, MD†,
- David A. Wood, MD⁎,
- Alexander B. Willson, MBBS⁎,
- Ronald K. Binder, MD⁎,
- Anson Cheung, MD‡,
- Jian Ye, MD‡ and
- John G. Webb, MD⁎,⁎ ()
- ↵⁎Reprint requests and correspondence:
Dr. John G. Webb, St. Paul's Hospital, 1081 Burrard Street, Vancouver, British Columbia V6Z 1Y6, Canada
Objectives The aim of this study was to evaluate vascular complications in a consecutive patient population undergoing transfemoral percutaneous aortic valve replacement (PAVR) applying current Valve Academic Research Consortium definitions.
Background Vascular complications have been the major cause of mortality and morbidity associated with PAVR. Both open surgical and fully percutaneous access site strategies have been advocated.
Methods All patients undergoing transfemoral PAVR during fiscal years 2009 and 2010 were prospectively evaluated at baseline, after the procedure, and at 30 days.
Results PAVR was performed in 137 consecutive patients. All but 1 patient underwent planned arteriotomy closure using a percutaneous pre-closure technique. Smaller sheaths, rigorous angiographic and computed tomographic screening and patient selection, and percutaneous vascular repair techniques were increasingly used over this period. From 2009 to 2010, major vascular complications decreased from 8% to 1% (p = 0.06), minor vascular complications decreased from 24% to 8% (p < 0.01), major bleeds fell from 14% to 1% (p < 0.01), and unplanned surgery decreased from 28% to 2% (p < 0.01). A minimal artery diameter smaller than the external sheath diameter, moderate or severe calcification, and peripheral vascular disease were associated with higher vascular complication rates.
Conclusions Vascular complications occur more often if the minimal artery diameter is smaller than the external sheath diameter, in the presence of moderate or severe calcification, and in patients with peripheral vascular disease. With careful patient selection, advanced interventional techniques, and a fully percutaneous procedure, marked reductions in vascular and bleeding complications can be achieved.
Drs. Toggweiler and Binder are supported by a grant from the Swiss National Foundation. Drs. Leipsic, Wood, Cheung, Ye, and Webb are consultants to Edwards Lifesciences. All other authors have reported that they have no relationships relevant to the contents of this paper to disclose.
- Received April 14, 2011.
- Revision received July 26, 2011.
- Accepted August 2, 2011.
- American College of Cardiology Foundation