Author + information
- Received July 18, 2011
- Revision received February 10, 2012
- Accepted February 14, 2012
- Published online May 22, 2012.
- Paul F. Frey, MD, MPH⁎,
- Peter Ganz, MD⁎,⁎ (, )
- Priscilla Y. Hsue, MD⁎,
- Neal L. Benowitz, MD†,
- Stanton A. Glantz, PhD‡,
- John R. Balmes, MD§ and
- Suzaynn F. Schick, PhD§
- ↵⁎Reprint requests and correspondence:
Dr. Peter Ganz, San Francisco General Hospital, Division of Cardiology, 1001 Potrero Avenue, 5G1, San Francisco, California 94110
Objectives The aim of this study was to investigate whether exposure to a range of relatively low concentrations of aged secondhand smoke (SHS), similar to those encountered commonly in the community, would impair endothelial function in a concentration-dependent manner.
Background Exposure to SHS impairs endothelial function in humans. The concentration-dependent relationship for aged SHS effects on endothelial function after an exposure of short duration is unknown.
Methods Thirty-three healthy nonsmokers were exposed to 1 of 2 low levels of aged SHS or to conditioned filtered air for 30 min. The primary end point was change in maximal percent brachial artery flow-mediated dilation after exposure.
Results In a linear regression model for each increase in SHS exposure by 100 μg/m3 respirable suspended particles, the absolute maximal percent brachial artery flow-mediated dilation was reduced by 0.67%. We did not find evidence of a threshold for the effect of SHS on flow-mediated dilation.
Conclusions Short-term exposure to real-world levels of aged SHS for 30 min resulted in a concentration-dependent decrease in endothelial function as measured by flow-mediated dilation.
Dr. Frey has received a post-doctoral research award for this study from the Tobacco-Related Disease Research Program. Dr. Benowitz has served as a paid consultant to pharmaceutical companies that are developing or market smoking cessation medications and has been a paid expert witness in litigation against tobacco companies. Dr. Schick and the operation of the exposure chamber and assays of tobacco smoke biomarkers were supported by the Flight Attendants Medical Research Institute Bland Lane Center of Excellence on Secondhand Smoke at the University of California, San Francisco. All other authors have reported that they have no relationships relevant to the contents of this paper to disclose.
- Received July 18, 2011.
- Revision received February 10, 2012.
- Accepted February 14, 2012.
- American College of Cardiology Foundation