|Life-threatening or disabling bleeding|
|Fatal bleeding (BARC type 5) OR|
|Bleeding in a critical organ, such as intracranial, intraspinal, intraocular, or pericardial necessitating pericardiocentesis, or intramuscular with compartment syndrome (BARC type 3b and 3c) OR|
|Bleeding causing hypovolaemic shock or severe hypotension requiring vasopressors or surgery (BARC type 3b) OR|
|Overt source of bleeding with drop in haemoglobin >5 g/dL or whole blood or packed red blood cells (RBCs) transfusion >4 units⁎(BARC type 3b)|
|Major bleeding (BARC type 3a)|
|Overt bleeding either associated with a drop in the hemoglobin level of at least 3.0 g/dl or requiring transfusion of two or three units of whole blood/RBC, or causing hospitalization or permanent injury, or requiring surgery AND|
|Does not meet criteria of life-threatening or disabling bleeding|
|Minor bleeding (BARC type 2 or 3a, depending on the severity)|
|Any bleeding worthy of clinical mention (e.g. access site hematoma) that does not qualify as life-threatening, disabling, or major|
BARC = Bleeding Academic Research Consortium (29); RBC = red blood cell.
↵⁎ Given that one unit of packed RBC typically will raise the hemoglobin concentration by 1 g/dl, an estimated decrease in hemoglobin will be calculated.