Author + information
- Franck Thuny, MD, PhD,
- Pierre Croisille, MD, PhD and
- Michel Ovize, MD, PhD⁎ ()
- ↵⁎Hôpital L. Pradel, Service d'Explorations Fonctionnelles Cardiovasculaires & CIC, Hospices Civils de Lyon, 59 Boulevard Pinel, 69394 Lyon Cedex 03, France
We thank Dr. Posada for his comments with regard to our recently published report (1). In this study, we analyzed the effect of post-conditioning on myocardial edema and infarct size. Patients with previous myocardial infarction in the same territory, a Thrombolysis In Myocardial Infarction flow grade >1, and evidence of coronary collaterals to the area at risk were excluded, to limit the influence of confounding factors. In Figure 1, we present additional information with regard to the distribution of the excluded patients according to the treatment allocation. Five control versus 7 post-conditioned patients were not included, due to absence or poor cardiac magnetic resonance imaging. Therefore, it seems that there was no imbalance in this distribution that might have biased the final results.
As previously demonstrated by our team, mechanical post-conditioning represents a feasible, safe, and efficient cardioprotective intervention (2). In this recent study, no adverse events occurred in the post-conditioning group. It is, however, important to stress that balloon deflation-reinflation as part of the post-conditioning protocol must be performed (immediately) upstream of the site of the culprit lesion (but not within the stent), to prevent microembolization that might thwart the protection of post-conditioning.
- American College of Cardiology Foundation