Author + information
- Juan Guillermo Duero Posada, MD⁎ ()
- ↵⁎University of Toronto, Postgraduate Medical Education, PGY4 Adult Cardiology Program, 500 University Avenue, Suite 602, Toronto, Ontario M5T 2S8, Canada
I read with interest the paper by Thuny et al. (1) published in the June 12, 2012, issue of the Journal. The authors adequately demonstrated the effectiveness of a post-conditioning strategy in decreasing the degree of myocardial edema as assessed by cardiac magnetic resonance and hypothesized how this can be the result of decrease in infarct size.
Post-conditioning is, of course, in early stages of development, and clinical implications remain to be established as clearly pointed out by the authors; the findings of this randomized trial make post-conditioning a very promising strategy for the ongoing improvement of outcomes in the management of ST-segment elevation myocardial infarction. As such, I am interested to learn whether the 26 patients not included in the analysis were evenly distributed between control/intervention groups, because this information can potentially affect the final interpretation of the results.
As post-conditioning transitions to becoming a clinically useful management strategy for ST-segment elevation myocardial infarction, data with regard to the safety of the intervention should be included in future research. Consequently, and given the potential role this paper can play in the design of future larger phase 3 clinical trials, I would appreciate if the authors could provide additional information on this issue.
- American College of Cardiology Foundation