Author + information
- Lori B. Daniels, MD, MAS⁎ (, )
- Elizabeth Barrett-Connor, MD,
- Gail A. Laughlin, PhD and
- Alan S. Maisel, MD
- ↵⁎Division of Cardiology, Department of Medicine, University of California, San Diego, Mail Code 7411, 9444 Medical Center Drive, La Jolla, California 92037-7411
We thank Drs. Lippi and Cervellin for their interest in our study (1). Although leukocyte count was not measured at the 1992 through 1996 Rancho Bernardo study visit, 802 (58%) of the 1,393 individuals in our study did undergo leukocyte count measurement in a previous visit approximately 4 years earlier. In these individuals, the correlation between potentially log (neutrophil gelatinase-associated lipocalin) and leukocyte count was only 0.14. We repeated the multivariable Cox proportional hazard models with leukocyte count included as a covariate, and the results were essentially unchanged, with only a very slight attenuation of the risk estimates. Neutrophil gelatinase-associated lipocalin was still a strong, independent predictor of cardiovascular disease death and of the combined cardiovascular end point in fully adjusted models that included leukocyte count. In addition, the association with all-cause mortality remained significant in models adjusted for age, sex, and leukocyte count, with borderline significance after adjusting further for other risk factors. Thus, neutrophil gelatinase-associated lipocalin seems to be an independent predictor of cardiovascular disease morbidity and mortality in older community-dwelling adults, independent of leukocyte count as well as traditional risk factors and renal function.
- American College of Cardiology Foundation
- Daniels L.B.,
- Barrett-Connor E.,
- Clopton P.,
- Laughlin G.A.,
- Ix J.H.,
- Maisel A.S.