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To evaluate the significance of non calcified plaques (NCP) on coronary CT for major adverse cardiac events (MACE), we followed subjects with NCP and analyzed coronary risk factors.
113 consecutive patients who underwent coronary CT (Light speed Ultra 16) from 2003 to 2004 and who had NCP in the coronary arteries (85 male; mean age, 67 ± 9 years; hypertension (HT), 72%; diabetes mellitus (DM), 30%; hyperlipidemia (HL), 54%; smokers, 61%; obese, 35%), were included. The patients were followed for a median of 74 (mean 59.8 ± 33.6) months after CT.
9 had a MACE. Patients with DM had a higher risk of MACE (17.6%) than those without (3.8%; p=0.013) during the observation period. Significant differences between the subjects with and without DM were seen at each time point and when the whole period of follow up was compared with a Kaplan Meier analysis and log rank test (p=0.006). A Cox proportional hazards model was used to test the significance of DM as a predictor of MACE considering influence of age, HT, HL, smoking and obesity. This analysis revealed that DM was a significant predictor of MACE (Hazard ratio 5.42, p=0.021). But no significant differences between subjects with and without HT, HL, smoking and obesity were observed with a Kaplan Meier analysis and log rank test.
Among subjects with NCP on CT, subjects complicated with DM had a higher risk of MACE than without following a median of 74 months using a Kaplan Meier analysis and Cox hazard regression with a hazard ratio of 5.42.
Poster Sessions, Expo North
Sunday, March 10, 2013, 9:45 a.m.-10:30 a.m.
Session Title: Imaging: CT/Multimodality VI
Abstract Category: 20. Imaging: CT/Multimodality
Presentation Number: 1230-371
- 2013 American College of Cardiology Foundation