Author + information
- Aju P. Pazhenkottil,
- René Nkoulou,
- Silke Kuest,
- Jelena Ghadri,
- Michael Fiechter,
- Tobias Fuchs,
- Bernhard Herzog,
- Ronny Buechel,
- Oliver Gaemperli and
- Philipp Kaufmann
New gamma cameras with Cadmium-Zinc-Telluride detectors (CZT) enable stationary whole heart acquisition. We sought to determine whether absolute coronary blood flow could be determined using these new cameras during a standard nuclear myocardial perfusion scan.
Twenty six patients referred for 1-d adenosine stress/rest myocardial perfusion SPECT with 99mTc-tetrofosmin were prospectively recruited. The absolute coronary blood flow (CBF) and the coronary flow reserve (CFR) were evaluated using 13N-ammonia PET (PET) and reassessed within two weeks using perfusion scanning with 99mTc-tetrofosmin on a CZT gamma camera. Results were compared using Pearson's correlation. The cut-off value of CZT CFR to predict abnormal PET CFR (<2) was determined using a receiver operator characteristic curve.
The mean CFR by CZT was 2.06 +/- 0.74 (stress CBF: 1.03 +/- 0.29 ml/g/min, rest CBF: 0.55 +/- 0.23 ml/g/min) comparing to the 2.19 +/- 0.67 (stress CBF: 2.07 +/- 0.69 ml/g/min, rest CBF: 0.95 +/- 0.22 ml/g/min) obtained with PET (p= NS). The CBF values by CZT correlated well with those obtained after PET (r= 0.806, p= 0.001). Thirteen out of 16 patients with preserved CFR by PET (> 2) and 8/10 with CFR < 2 were accurately characterized by CZT (agreement rate: 80.7%).
Nuclear myocardial perfusion imaging on a CZT gamma camera allows quantification of CBF with accurate depiction of abnormal CFR compared to PET which is added information in the functional characterization of coronary artery disease.
West, Room 3001
Sunday, March 10, 2013, 11:30 a.m.-11:45 a.m.
Session Title: Nuclear Cardiology and PET: Pushing the Boundaries
Abstract Category: 21. Imaging: Nuclear
Presentation Number: 926-6
- 2013 American College of Cardiology Foundation