Author + information
- Usman Baber,
- Samantha Sartori,
- Roxana Mehran,
- Erling Falk,
- Mario Garcia,
- Valentin Fuster and
- Henrik Sillesen
Stroke risk is significantly higher among African-Americans (AA) compared to Caucasians (C). Whether this reflects racial differences in carotid atherosclerosis is unknown.
In the BioImage study, 5,276 asymptomatic adults underwent multimodality noninvasive imaging for subclinical atherosclerosis evaluation in the carotid and coronary arteries using duplex ultrasound and computed tomography (CT). Subclinical carotid atherosclerosis was defined as any focal carotid plaque with local thickening of >0.5 mm.
AA (n=898, 17.0%) were slightly younger (68.0±5.7 vs 69.1±6.1 years (P<0.001), more often diabetic (23.3% vs 11.4%, P<0.001) and hypertensive (67.5% vs 48.4%, P<0.001) when compared to C (n=4378, 83.0%). Any subclinical carotid atherosclerosis was significantly less common among AA compared to C (66.0% vs 80.4%, P<0.001). While prevalent carotid atherosclerosis increased with older age, racial differences persisted across age categories (Figure 1). An inverse association between AA race and prevalent carotid atherosclerosis was unchanged after multivariable adjustment (Odds Ratio [95% CI]: 0.48 [0.41-0.57]).
Despite the greater burden of hypertension and diabetes, carotid atherosclerosis is significantly less common among AA vs C in the BioImage Study. These findings suggest that the increased stroke risk in AA may be due in larger part to non-atherosclerotic mechanisms such as hypertension or diabetes.
Poster Sessions, Expo North
Sunday, March 10, 2013, 3:45 p.m.-4:30 p.m.
Session Title: Imaging: CT/Multimodality VII
Abstract Category: 20. Imaging: CT/Multimodality
Presentation Number: 1269-343
- 2013 American College of Cardiology Foundation