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Increased epicardial adipose tissue(EAT) and progression of noncalcified plaque volumes(NCPV)are directly associated with coronary artery disease and independently predict cardiovascular mortality. This study evaluates the relation of change in EAT and NCPV measured by computed tomography angiography(CTA) in response to statin-therapy.
One hundred and six consecutive-subjects (age 67±9 years, 80.7% men, 31 with statin-therapy and 75 without statin-therapy) who underwent serial clinically indicated CTAs with median-interval of 1.2 year, were studied. EAT, adipose tissue inside pericardial sac, was measured from slice level 15 mm above to the bottom of the heart. NCPV of target segment with luminal stenosis<50% were measured quantitatively using Vitrea-software.
There was no significant difference in EAT and NCPV among subjects with and without statin-therapy at baseline(p>0.05). At follow-up, there was a significant decrease in EAT in individuals with statin-therapy as compared to those without statin-therapy(−16.2% vs. 34.6%, p=0.0001). A significant decrease in NCPV in statin-therapy group was noted(p<0.05). A significant correlation between decrease in EAT and NCPV was noted(r2=0.45, p=0.0001). Risk factor adjusted median decrease in EAT and NCPV were 176% and 144% more in statin-therapy as compared to those without statin-therapy.
There was a strong relation among decrease in EAT and decrease in NCPV in response to statin-therapy.
Poster Sessions, Expo North
Sunday, March 10, 2013, 3:45 p.m.-4:30 p.m.
Session Title: Imaging: CT/Multimodality VII
Abstract Category: 20. Imaging: CT/Multimodality
Presentation Number: 1269-344
- 2013 American College of Cardiology Foundation