Author + information
- Annika Schuhbaeck,
- Damini Dey,
- Yuka Otaki,
- Brian Kral,
- Piotr Slomka,
- Ryo Nakazato,
- Stephan Achenbach,
- Daniel Berman,
- Eliott Fishman,
- Shenghan Lai and
- Hong Lai
Coronary Computed Tomography angiography (CTA) can characterize calcified and non-calcified plaque. Quantitative measurements of coronary plaque volume may play a role in serial studies to determine disease progression or response to medical therapies. Our aim was to evaluate the interscan reproducibility of quantitative measurements of coronary plaque volume and composition from coronary CTA, using a standardized automated method.
Coronary CTA (Dual Source or Single Source CT, 64×0.6mm collimation, 120 kV tube voltage,150 or 600 mAs tube current) was performed twice for research purposes in 21 consecutive patients (14 males) within a maximum time difference of 100 days (mean 23.0±24.1 days). For each patient, the total plaque volume, the volume of non-calcified (NCP) and calcified (CP) as well as the maximal remodeling index were determined in both data sets using automated software (Autoplaq). This software combines patient-specific attenuation thresholds for lumen, NCP and CP, and knowledge-based arterial segmentation.
There was no significant difference regarding the total coronary plaque volume (615.0±552.8mm3for the first vs. 602.5±501.6mm3for the second scan, p=0.74), the CP volume (123.9±271.9 mm3vs. 92.0±190.3mm3, p = 0.11) or NCP volume (491.1±412.1mm3vs. 510.5±371.6mm3, p = 0.63) between both scans. There was excellent interscan correlation of the plaque volumes (r=0.96, r = 0.99 and r = 0.90 for total plaque, NCP, and CP volumes, respectively). The maximal remodeling index was 1.7±0.5 for the first and 1.6±0.4 for the second scan (p = 0.07, r = 0.66).
The reproducibility of coronary atherosclerotic plaque volume in coronary CTA is high when automated software is used for quantification. With this approach, serial studies to determine progression or regression of coronary atherosclerotic plaque appear to be possible.
Poster Sessions, Expo North
Sunday, March 10, 2013, 3:45 p.m.-4:30 p.m.
Session Title: Imaging: CT/Multimodality VII
Abstract Category: 20. Imaging: CT/Multimodality
Presentation Number: 1269-346
- 2013 American College of Cardiology Foundation