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Motion-frozen (MF) image reconstruction by QGS software was previously reported on the improvement of image quality in comparison to standard filtered back-projection (FBP). Diagnostic performance of MF reconstruction for the detection of coronary artery disease (CAD) in patients with normal ejection fraction (EF) and impaired EF has not been reported.
We compared diagnostic performance of MF reconstruction between normal EF (≥50%, n=105) and impaired EF (<50%, n=51) groups. We calculated stress-induced ischemia using total perfusion deficit (TPD) for both FBP and MF reconstruction datasets. ROC analyses were performed in FBP-TPD and MF-TPD groups with regard to significant coronary stenosis (≥75% stenosis) in both normal EF and impaired EF groups.
The area under the ROC curve (AUC) of MF-TPD for the detection of CAD was significantly better than FBP-TPD in normal EF group (0.857 vs 0.804 for MF-TPD and FBP-TPD, respectively). However, the AUC of MF-TPD and FBP-TPD in impaired EF group was not significantly different (0.806 vs 0.755 for MF-TPD and FBP-TPD, respectively).
Motion-frozen myocardial perfusion SPECT improves detection of CAD in patients with normal left ventricular function, but did not improve it in patients with impaired EF group.
Poster Sessions, Expo North
Sunday, March 10, 2013, 3:45 p.m.-4:30 p.m.
Session Title: Novel Applications of SPECT and PET
Abstract Category: 21. Imaging: Nuclear
Presentation Number: 1271-356
- 2013 American College of Cardiology Foundation