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Although left ventricular (LV) morphology and function have been well demonstrated in hypertrophic cardiomyopathy (HCM), few data exist regarding right ventricular (RV) ones in HCM.
Methods and Results
We examined 65 HCM patients (39 men, age 61.5±21.9 years) with maximal LV thickness > 15 mm who underwent cardiac magnetic resonance imaging. RV hypertrophy, defined as RV maximal wall thickness > 5mm, was observed in 18 of 65 patients (RVH group). Compared with the non-RVH group, the RVH group showed higher BNP levels (408±302 pg/ml vs. 240±227 pg/ml, p=0.04) and higher prevalence of heart failure (77.7% vs. 16.6%, p<0.0001). Although LVEF and RVEF were not different between two groups, the RVH group showed reduced RV end diastolic volume index (48.8±14.3 ml/m2vs. 61.3±13.0 ml/m2, p=0.02) in accordance with greater LV mass index (LVMI) (111.4±23.3 g/m2vs. 74.4±22.5 g/m2, p<0.0001). Interestingly, the RVH group was highly associated with RV-late gadolinium enhancement (RV-LGE) in comparison with the non-RVH group (55.5% vs. 0%). Multivariable analysis revealed that LVMI, BNP levels, and RV-LGE associated with RVH were independent predictors of heart failure. During follow up period, the RVH group had higher incidence of cardiovascular events, such as ventricular tachyarrhythmia, stroke and heart failure admission (p=0.01) than the non-RVH group.
These results demonstrate that HCM with RVH can be associated with severe clinical phenotypes in comparison with non-RVH patients.
Poster Sessions, Expo North
Sunday, March 10, 2013, 3:45 p.m.-4:30 p.m.
Session Title: Imaging: MRI V – CMR in Hypertrophic and Infiltrative Cardiomyopathies
Abstract Category: 19. Imaging: MRI
Presentation Number: 1272-363
- 2013 American College of Cardiology Foundation